Cure Multiple Sclerosis Web Site - UNDER CONSTRUCTION - new urls = CureMS.no-ip.org & FightMS.no-ip.org

***** Sorry but this project is on hold due to lack of funding *******

We are making robot mowers if we can generate some income this project will start up again

Latest MS research: New MS gene discovered at Georgetown

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MS lesions

Take Control of Your Disease. You Can Have an Impact. Get What You Really Want. A Cure.

You can help find a cure for MS by providing the use of your home computer to search for molecules that could cure MS. By obtaining the 3D structure files of proteins that possibly effect MS from public databases and trying to " dock" possible drug smaller molecules at the large proteins' active sites, we hope to find drug candidates for the treatment of MS. The molecules are moved and rotated in an exhaustive search until possible binds are found. Other distributed computing projects

Our first search will be for small molecules(ligand) that will bind with interferon-gamma's receptor site. Interferon gamma is one of the proteins involved in the human immune system. It appears that this molecule seems to inhibit MS activity in mice, but increase it in humans. If we can find a human friendly molecule that binds with the receptor site of interferon gamma. It may result in a treatment for MS. Become a MS disease modeler.

How it works ****** This next link is for MS researchers to review possible shared tools --> Shared researcher tools

Other target proteins we plan to explore: TNF( p75nTR, fas, p55) HDL-Dr2, CD4 T-Cell( CD4-Compath complex), PLP

BTN/MOG

Upcomoing projects for this web site

  • It's all greek to me ! For those of you that can't understand any of those $5 words these researchers use, we are also developing a MS research literature database of the entire body of MS research papers with hypertext dictionary links on all those hard words. We believe that by empowering the community of MS patients to better understand their disease, they can better assist in the pursuit of a cure.

    Try the original document. Then try the layman's version. Learn the basics. Here's MIT's Biology Hypertextbook, Online Medical Dictionary, Online Cybernetic Dictionary, How do DNA chips and microarrays work

  • A database of all:
  • MS research efforts. Past and present.
  • Process steps for each research team.
  • Semantic network model of each MS research effort.
  • A mapping via the semantic map of all possible areas of collaboration.
  • All proteins invloved in the MS disease model. All versions of these protein's life cycles.
  • Protein network maps. How the proteins interrelate in the myelination/demyelination process.
  • Pathways and cellular signaling maps of all biological processes that may relate to MS.
  • Glycobiology links to pathways and signaling maps of all related glycocarbohydrates and glycolipids.
  • Bio Cad - Computer Aided Design System and simulator of the entire MS disease model.
  • A distributed webcralwer that gathers and automatically updates a database of all references to Multiple Sclerois on the web
  • Once we have organized all the current data on Multiple Sclerosis we will begin running millions of evolving genetic algorithms that will continually self-organize neural networks that will perform a massive search for cures and treatments for MS. Download this simple but amazing example of a genetic agolrithm organizing hundreds of simple neural networks

    Here are some MS researchers who have expressed interest in working with this project. They are the front line in the race to find cures and treatments for MS. This project seeks to provide them with not only massive computing power but an army of informed lab assistants that can help in enhancing and greatly accellerating their research. In addition to harnessing the power of thousands, maybe millions, of your computers, we are hoping to harness your minds in one huge "Master Mind" effort. Smaller groups of volunteers are sought to select one area of research or research team to assist. Focusing the group's efforts on a specific course of research.

  • Lynn Hudson
  • Nadja Kadom
  • Roland Martin
  • Ramchandran Murali - U of Penn
  • Steven E. Pfeiffer
  • Murali Ramanathan
  • John Richert
  • For those of you wanting to play with Interferon gamma while we finish building this site, here are some downloads of key elements.
  • Global Range Molecular Matching This is a public domain 3D molecule Geometric and Hydrophobic Docking program courtesy of Ilya Vakser and his Lab at Stony Brook University. What does hydrophobic mean?
  • Molecule Viewer(RasMol) This is a public domain 3D molecule viewer courtesy of Roger Sayle. You can use it to look at the molecules that are being run on your system. Human Interferon Gamma sturcture file

    Try this link if you want to Download All Three.

  • If you are invloved in any research programs, let us know about it. This is project is currently not funded. So if you have any computer or programming background and would like to help, please contact us. Donate $1 to our web site.

    Contact: Peter James 301 916-5722 other MS links

    Blair HS student projects page